Endocrine Abstracts

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

Introduction: Vitamin D (Vit D) receptors have been shown in extra skeletal tissues. Vit D deficiency plays a role in the development of many malignant, chronic inflammatory, autoimmune and metabolic diseases. Our aim was to evaluate the effect of Vit D replacement therapy on insulin sensitivity, endothelial function and oxidative stress in Vit D deficient subjects.Material-method: Serum 25(OH) D levels of 74 volunteer-healthy subjects (22.7±2.7) we...

Aim: Peak bone mass is a major determinant of osteoporosis risk in later life. It is under strong genetic control; In the present study, we investigated the relationship between polymorphisms in the gene encoding the vitamin D receptor (VDR) (FokI and Bsm 1) and bone mineral density (BMD), bone mineral content (BMC), and markers of bone turnover in 106 young Turkish women (19–23 yrs) and 100 man (19–23 yrs). Methods: BMD and BMC were measured by dual-energy X-ray abs...